Curriculum Vitae

Curriculum Vitæ

[Compact CV on Aviesan] [3-pages academic summary]

[Employment] [Education] [Publications] [Lectures] [Awards] [Training] [Grants] [Community]

Employment history

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Since 2023 Senior scientist CNRS, European Genomic Institute for Diabetes, Lille, FR PIs: Amélie BONNEFOND, Philippe FROGUEL
2019-2023 Consultant in data analysis, modelling, science copywriting, and language translation aSciStance Limited, Cambridge, UK Founder and director
2012-2018 Senior Group leader Babraham Institute, Babraham, Cambridge, UK
2014-2015 Chief Data Officer Curie Institute, Paris, FR
2003-2012 Group leader EMBL-EBI, Hinxton, Cambridge, UK
2001-2003 Researcher CNRS URA 2182, Récepteurs et Cognition, Institut Pasteur, Paris, FR PI: Jean-Pierre CHANGEUX
1999-2001 Post-doctoral fellow Computational Cell Biology, University of Cambridge, Cambridge, UK PI: Dennis BRAY
1992-1999 Undergraduate, PhD student, and post-doctoral fellow CNRS URA D1284, Neurobiologie Moléculaire, Institut Pasteur, Paris, FR PI: Jean-Pierre CHANGEUX
1991 Undergraduate student INSERM 153, Service of Développement, Pathologie, Régénération du système neuromusculaire, Institut du fer à moulin, Paris, FR PI: Michel FARDEAU

Educational and professional qualifications

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2013 Habilitation à diriger des recherches University Bordeaux II Segalen
2010-present Directeur de Recherche (senior scientist) CNRS
2001-2010 Chargé de Recherche (research fellow) CNRS
1994-1998 PhD in Molecular and Cellular Pharmacology University Paris VI Pierre et Marie Curie
1992-1993 Diploma of Advanced Studies (Master Degree) in Molecular and Cellular Pharmacology University Paris VI Pierre et Marie Curie
1990-1993 Magistere in Biology-Biochemistry École Normale Supérieure
1991-1992 Master of Cellular Biology [Evolution; Neuroendocrinology; Molecular Biophysics] University Paris VI Pierre et Marie Curie and Paris XI
1990-1991 Licence (Bachelor) of Cellular Biology and Physiology University Paris VI Pierre et Marie Curie
1988-1990 Advanced maths classes preparing for the Grandes Écoles Lycée Camille Guérin of Poitier
1988: Scientific baccalaureate Prytanée National Militaire of La Flèche

Teaching and supervision

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Post-docs

Marwa Afnouch (2024-), Lu Li (2013-2018), Piero Dalle-Pezze (2016-2018), An Nguyen (2015-2018), Pınar Pir (2012-2015), Martina Froehlich (2012-2015), Junmei Zhu (2012), Vladimir Kiselev (2011-2015), Massimo Lai (2010-2015), Éric Fernandez (2004-2005),

PhD supervisions

Omaima Binan 2024-
Manusnan Suriyalaksh 2016-2018 A systems approach to identify novel ageing regulators in Caenorhabditis elegans
Juliette Ellen Pearce 2016-2018 Modelling metabolic landscapes in human naive and primed embryonic stem cells
Janna Hastings 2015-2018 Metabolic influences on ageing in Caenorhabditis elegans
Vincent Russell Knight-Schrivjer 2014-2018 Towards systems pharmacology models of druggable targets and disease mechanisms
Benedetta Frida Baldi 2009-2015 Modelling at the Mesoscale: a Novel Approach to Protein-Protein Interaction and Multicomplex Formation
Christine Seeliger 2009-2014 Spatial and Stochastic Modeling of TrkB Mediated Signaling Pathways Involved in Long Term Potentation in the Dendritic Spine
Michele Mattioni 2008-2012 Multiscale Modelling in Neuroscience: Integration of computer simulations of biochemical and electrical signalling in the medium spiny neuron of the striatum
Lu Li 2007-2010 Modelling dopamine and glutamate signal integration
Melanie I Stefan 2006-2009 On the function of calcium-regulated allosteric devices in synaptic plasticity
Dominic P Tolle 2005-2009 Investigating the Consequences of AMPA Receptor Diffusion on Long-term Potentiation using Single-Particle Modelling Approaches
Zhi-Yan Han 1999-2002 Contribution à l'étude des récepteurs nicotiniques de l'acétylcholine dans le cerveau du singe rhésus

PhD visitors

Lucas Marmiesse (2015), Anna Zhukova (2016), Youwei Zheng (2011), Nathan Skene (2010), Ron Henkel (2009), Koray Dağan Kaya (2008), Guillaume Guerlet (2008), Christian Knüpfer (2007), Dagmar Köhn (Waltemath) (2007)

PhD juries

Anwesha Bohler (2017), Lucas Marmiesse (2016), Sylvain Soliman Habilitation (2015), Samuel Croset (2014), Lukas Endler (2012), Allyson Lister (2011), Andrew Miller (2011), Dagmar Köhn (Waltemath) (2011), Aurelien Rizk (2011), Carito Guziolowski (2010), Sarala Wimalaratne (2009), Benjamin Hall (2007), Pim Van Nierop (2007), Stéphanie Weiss (2006), Anne-Sophie Villegier (2005), Geoffroy Golfier (2004)

Undergraduate interns

Arthur Six (2025), Sami Le Guilcher (2024), Adrien Leroy (2018), Stephen Cole (2017), Agathe Delaune (2017), Derya Sebukhan (2017), Letizia Vestito (2017), Katrīna Daila Neiburga (2016), Krutic Patel (2016), Hoa Le (2014), Ioana Olan (2014), Simon Delagneau (2014), John Gowers (2013), Grigalius Taukanska (2013), Marija Jankovic (2013), Yangyang Zhao (2012), Ishan Ajmera (2011), Denis Brun (2011), Michael Schubert (2011), Anna Zhukova (2011), Gael Jalowicki (2011), Jean-Baptiste Pettit (2010), Karim Tazibt (2010), Marine Dumousseau (2009), Ranjita Dutta-Roy (2008), Kedar Nath Natarajan (2008), David Marshall (2007), Antonia Mayer (2007), Anika Oellrich (2007), Enuo He (2006), Arnaud Henry (2006), Camille Laibe (2006), Renaud Schiappa (2006), Lu Li (2005), Alexander Broicher (2004), Marie-Ange Djite (2004).

Courses

Organiser (and lecturer)

EBI course In silico systems biology (2010-2018); Cajal Advanced Neuroscience Course Bioinformatics for the neuroscience (2015); WT/E-MeP Advanced Training Workshop in Bioinformatics of Membrane Proteins, Hinxton, UK (2008); Okinawa Computational Neuroscience Course 2006, OIST, JP (2006).

Lecturer

Graduate program Precision Health, Lille (2024), Master 2 Bioinformatique, Lille (2024); Part III Systems Biology, University of Cambridge, UK (2013-2018); Natural Science Tripos, University of Cambridge, UK (2017); Gebze Technical University Molecular Biology and Genetics Undergraduate program (2017); Cambridge University Technical College (2015, 2017); Advances in Systems and Synthetic Biology, Strasbourg (2015); EBI course "The Systems Biology Modelling Cycle", Hinxton, UK (2014); Instituto Gulbenkian de Ciência PhD student course, Lisbon, PT (2012); SystemsX.ch/SIB Summer School, Kandersteg, CH (2011); Summer school of the Center for Genomic Regulation, Barcelona, SP (2011); EBI-Wellcome Trust Summer School in Bioinformatics (2010, 2011, 2012); International Genetically Engineered Machine competition (iGEM) - Cambridge (2007, 2009); EBI training on Networks and Pathways (2009); APO-SYS data management workshop, Hinxton, UK (2008); SysBioMed Winter School, Tenerife, ES (2007); EMBL international PhD program, Heidelberg, DE. (2005, 2007); Symbionic course on Methods, data handling and standards in neuronal systems biology, Trieste, IT (2005); FEBS course 1st Advanced Course on Systems Biology: From Molecules & Modeling To Cells, Gosau, AT (2005); ESF course Modelling Metabolic and Signal Transduction Networks, Oxford, UK (2005); Diploma of Advanced Studies of Neurobiology and Pharmacology (École Normale Supérieure), Paris, FR (2002).

Awards and fellowships

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2003 JM Le Goff Award French Academy of Science (for bioinformatics analysis of the ligand-gated ion channels receptors of neurotransmitters)
1999-2001 long term fellowship European Molecular Biology Organisation
1998-1999 Allocation Roux Institut Pasteur
1994-1997 PhD scholarship French Ministry of Research

Professional memberships

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2017-2018 Faculty of 1000 Head of section Network and Systems Biology
2014-2016 International Society for Stem Cell Research
2010-2018 International Society for Computational Biology Senior member from 2016, Board of directors 2017-2018
2007-present International Society of Systems Biology Executive board
1995 The Society for Molecular Biology & Evolution

Grants

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IDEx University of Lille NEXT-GENeration PRecIsion medicine in Inflammatory and MEtabolic diseases co-I 01/09/2025 - 30/08/2029
ANR Éclairer le métabolome obscur du microbiote intestinal humain avec la chimiométrie et la chémoinformatique adaptées à l'UHPLC-MS co-I 01/10/2024 - 31/09/2027
Région Hauts-de-France STaRS, Soutien à l’accueil de Talents de la Recherche Scientifique. AI models to reveal molecular networks underpinning the prediction of metabolic and inflammation disorders PI 01/09/2024 - 31/08/2026
IHU2 PreciDIAB Outils d’Apprentissage Profond pour appuyer la médecine de précision dans le diabète et affections apparentées co-I 01/02/2024 - 30/04/2026
MRC JPND - Intraneuronal transport-related pathways across neurodegenerative diseases co-PI 01/04/2018 - 30/06/2021
BBSRC Molecular and Cellular Mechanisms of Host Defence and Immunosenescence, a BBSRC Strategic Programme co-I 01/04/2017-31/03/2022.
BBSRC Epigenetics and cellular heterogeneity in development and ageing, a BBSRC Strategic Programme co-I 01/04/2017-31/03/2022.
BBSRC Molecular mechanisms underpinning healthy ageing, a BBSRC Strategic Programme co-I 01/04/2017-31/03/2022.
NIH Continued support and development of SBML co-I 01/05/2016-30/04/2019.
BBSRC MultiMod, flexible management for multi-scale multi-approach models in biology co-PI 01/06/2016-31/05/2019.
EU Commission COST action CHARME co-I 2016-2018
BBSRC UK Multi-Scale Biology Network co-I 06/2015-05/2018.
BBSRC Software hardening and training in epigenetics and systems biology co-I 2015-2017.
MRC Modification of the host lipidome by Rhinovirus infection co-I 03/07/2014-2018
BBSRC CASE Systems Pharmacology Models of Druggable Pharmaceutical Targets and Disease Mechanisms PI 31/03/2014-30/03/2018.
EU commission Systems biology of pathways involving brain ageing (AgedBrainSYSBIO) co-PI 01/01/2013-30/06/2017
BBSRC ISP A systems approach to understanding lipid, Ca2+ and MAPK signalling networks co-I 01/04/2012-31/07/2017.
BBSRC Linking data with Identifiers.org co-I 08/2013-11/2014
EU commission Infrastructure for Systems Biology Europe (ISBE) co-I 27/09/2012-
BBSRC BBR BioModels Database, the comprehensive resource for computational models in Biology PI 01/08/2012-30/07/2015
IMI-JU Open PHACTS co-I 01/02/2012
BBSRC How do cells shape and interpret PIP3 signals co-I 01/05/2011-30/04/2016.
IMI-JU Drug Discovery Model Repository (DDMoRe) co-I 01/03/2011-28/02/2016.
BBSRC First COMBINE meeting: Bridging model structure, semantics and representation. PI 06/10/2010-09/10/2010.
NIH Continued support and development of SBML co-I 01/09/2010-31/12/2012.
EU commission Synaptic Systems: dissecting brain function in health and disease (SynSys) co-I 01/07/2010-30/06/2014.
EU Commission ELIXIR technical feasibility study 13.3 co-I 01/03/2008-31/08/2009
BBSHDRRC BBR BioModels Database: a unified resource for Systems Biology models. PI 01/01/2008-31/12/2011
NIH Continued support and development of SBML co-I 01/09/2007-31/08/2010.
BBSRC Interfacing standards and ontologies in Systems Biology. co-PI 01/04/2007-31/03/2011
BBSRC Software infrastructure to support the standard of model curation and annotation MIRIAM. PI 01/09/2006-31/08/2007
NEDO Development of The Systems Biology Graphical Notation, a standard graphical notation for diagrams of computational models in biology co-PI 01/11/2005-30/06/2008
NIH Continued support and development of SBML co-I 01/09/2005-31/01/2007
EU commission The European Membrane Protein Consortium (e-MeP) co-I 01/07/2004-31/03/2009.
ESF The Meso-telencephalic Dopamine Consortium (DopaNet). PI 01/01/2003-31/12/2005.

Community involvement and management of science

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Member of the editorial board

NPJ Systems Biology and applications (associate editor 2014-2018), PeerJ (2012-2014), BMC Systems Biology (2006-2018, associate editor 2008-2018).

Meeting organisation

EMBO meeting 2015 special interest symposium on epigenetics and cell fate, COMBINE 2013, COMBINE 2012, COMBINE 2011, COMBINE 2010, HARMONY 2012, HARMONY 2011, SBGN 4, SBGN 3.5, SBGN 3, SBGN 2.5, SBGN 2, SBGN 1, SBML hackathon 2009, SBML hackathon 2004.

Member of conference scientific committee

Joint SysMod 2018, Joint SysMod 2017, Joint SysMod 2016, Joint SysMod/NetBio 2016, ISMB/ECCB 2017, ISMB/ECCB 2015 (chair of the "systems" theme) BioNetVisa 2017, BioNetVisa 2016, BioNetVisa 2015, BioNetVisa 2014, FMMB 2014, CBIBM 2014, ICBO 2013, ICBO 2012, CIBB 2009, BioSysBio 2009, BioSysBio2008, ECCB 2008, ICSB 2016, ICSB 2014, ICSB 2010, ICSB 2008, ICSB 2006, CMSB 2008, CMSB 2005.

Standardisation editorial boards

Simulation Experiment Description Markup Language (2008-2013), Systems Biology Graphical Notation (2008-2012), Systems Biology Markup Language - SBML (2006-2008, 2011-2013, 2016-2018), Co-chair of the IUPHAR sub-committee on the nomenclature of nicotinic acetylcholine receptors.

Grant panels

Swiss National Fund's Sinergia (2016-2018), ERC Advanced Grants (2015-2018), MRC Biomedical Informatics Fellowship (2014), FRM Bioinformatics (2013, 2014), Forschungszentrum Juelich GmbH (2013), agreenskills (2013), BMBF eBio (2011), BBSRC TRDF (2010) and STRDF (2011), ANR SYSCOMM (2008, 2009), ANR/BBSRC Systems Biology (2007)

Steering committee

UK Multi-Scale Biology community network (2015-), AgedBrainSYSBIO (2013-2017),The European Membrane Protein Consortium - E-MeP (2004-2007)

Scientific advisory committees

Toulouse's Centre of Integrative Biology (2016-2018), Cochin Institute (2016-2018), COPASI BBR (2013-2018), Heidelberg's Centre for Organismal Studies (2013-2018), Montpellier's Pôle Biosanté Rabelais (2013-2018), labex EpiGenMed (2013-2018), BioPAX (2010-), German Virtual Liver Network (2010-2014), Research Centre of the Institut Curie (2009-2018), BBSRC Plant Models Portal (PLaSMo, 2008-2010), EU IP ENFIN (2005-2010), UK Quantitative Systems Pharmacology Network, AERES.

Expert groups

Science Europe “Multidisciplinary career paths” (2015), BBSRC “Digital Organisms” (2012), EU “Systems Biology for Medical Applications” (2007), Inserm “Tobacco: Understand the addiction to act” (2003)